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hello i am pierce woodber sorens and iamp;#39;m a neurologist from the danish muscle sclerosis center at the university of copenhagen and iamp;#39;m happy to be invited to give you this presentation on registers in the real world evidence generation and these are my disclosure of conflicts of interest so what is in fact real world evidence well you know the uh fda defined real worldamp;#39;s evidence as a clinical evidence regarding the usage and potential benefits and risk of a medical product derived from analysis of real world data and real world evidence can be generated from different studies including but not limited to randomized clinical trials but also including large simple trials pragmatic trials and observational studies both prospective and retrospective so how do we get real-world data yet the main sources are data registers and databases but also administrating claim data and medical records are used and recently also the variable devices can produce data so w