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on top of that we have another drug which I would like to hear a little bit of thoughts on but before we go to the talk about trimester of AB I would like to go back to Catherine AFB whatamp;#39;s AFB thatamp;#39;s a great question if he is is a protein that is released by hepatocellular carcinoma as well as other cancers itamp;#39;s been reported in as well as the liver itself when it is injured and regenerating and I explained it to my patients as AFP is a sign of liver cell growth and regeneration so for instance in someone with an acute liver injury we want to see a high AFP to tell us that the liver is trying to heal so it has been shown that patients who have liver cancer with a high AFP are a little bit worse prognosis patients and but we also know itamp;#39;s not a perfect test because many liver cancers donamp;#39;t release AFP at all so itamp;#39;s itamp;#39;s a tool but itamp;#39;s only one tool and you canamp;#39;t hang your hat on the whole story with that importa