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and our next speaker is lookig Arase who is a postdoctoral fellow in Peter sagres lab where he studies signaling dynamics of ear k of the ear k pathway in Beira in b-raf resistant cancers and they believe he is gonna tell us something about how these dynamics contribute to cancer resistance due to a drug resistance of cancers Thank You Nikolai for the introduction and the organizers for this great conference I need to apologize already thereamp;#39;s not gonna be any single cell proteomics data in this talk but what Iamp;#39;m going to speak is single cell data and hopefully a mechanism used by cancer but really relies on single cell behaviors and therefore could be a good biological process but will be possible to study with single cell proteomics maybe just to put you in the context of the cancer problem but Iamp;#39;m studying during my postdoc which is adaptive resistance to target therapy in cancer I just want to remind you that human cells transduce mutagenic signals coming fr