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Institutional Review Boards (IRBs) play a critical role in protecting participants in federally funded research, as mandated by the Common Rule. Before enrolling individuals in a study, researchers must submit their proposals to an IRB for review and approval. The IRB ensures that research adheres to ethical standards and regulations, particularly for vulnerable populations like prisoners and children. The committee examines various aspects of the study to guarantee participant safety; if any issues arise, approval will be withheld until necessary modifications are made. The video outlines the IRB's function and emphasizes its importance in ethical research involving human participants.