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Institutional Review Boards (IRBs) A set of Federal regulations known as the Common Rule protects people who participate in federally funded research. The regulations require that a committee review and approve a study before allowing people to enroll in the research. This video explains the role of these committees, which are called institutional review boards or IRBs. What is an IRB? An IRB is a committee that reviews research studies to make sure that they follow ethical standards and regulations for research with people. In addition to the Common Rule, there are regulations to protect people who may need more protection, such as prisoners and children. When a research study involves human participants, researchers submit the proposed study to an IRB for review. The IRB looks at many different aspects of the study to make sure it meets the requirements for protecting those people. If it doesnt, the IRB will not approve it until the necessary changes are made. IRB review does n