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The NMDA receptor, one of two primary glutamate receptors, alongside the AMPA receptor, often coexists at the same synapse, such as in the CA1 region of the hippocampus. When weak electrical stimulation of the presynaptic neuron occurs, glutamate is released and binds to both AMPA and NMDA receptors. Weak stimulation typically activates only AMPA receptors, leading to slight depolarization of the postsynaptic neuron. Although NMDA receptors are also permeable to sodium and potassium ions, minimal ion flow happens when these receptors are activated at slightly depolarized resting membrane voltages due to a magnesium ion blockage within the channel, which restricts ion passage.