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the NMDA receptor is one of two main kinds of receptors activated by glutamate the other main kind of glutamate receptor is called the AMPA receptor these two receptors each with distinct physiological properties often coexist at the same synapse shown here is a model synapse in the ca1 region of the hippocampus containing both types of receptors weak electrical stimulation of the presynaptic neuron causes the release of glutamate from the axon terminal this glutamate binds to both ampa and nmda receptors although both NMDA and AMPA receptors are permeable to sodium and potassium ions weak stimulation normally activates only the AMPA receptors resulting in a slight depolarization of the postsynaptic neuron when glutamate binds to the NMDA receptor at slightly depolarize door resting membrane voltages very few ions flow through the channel this low conductance occurs because the pore of the channel is blocked by magnesium ions which prevents other ions from passing freely through the c
