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In America, the blood industry is a multibillion-dollar enterprise, valued at $3.3 billion in 2021, with blood accounting for over 2% of U.S. exports. The demand for blood is high and often hard to meet, resulting in a critical one-day supply at times, which can impact public health. Despite its life-saving importance, challenges remain, particularly regarding the FDA's blood donation policies that historically banned gay men from donating. This ban is under scrutiny as recent studies suggest a need for change. Major companies like Grifols, CSL Plasma, Takeda's BioLife, and Octapharma dominate blood collection, particularly plasma, which is compensated and used for therapies by pharmaceutical companies.