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this tutorial will teach you how to use Pico a model that outlines your clinical research question it acts as a framework asking you to think specifically about different aspects of what you want to investigate and is a fundamental part of evidence-based research the first four letters are generally always needed while the two Ts on the end may be optional lets start with the first 4p is for patient or population who is receiving the treatment and what are their characteristics I is for intervention or interest what do you plan to do such as a specific treatment or therapy c is for comparison what are alternative methods or treatments to your intervention and O is for outcomes what you expect to see or want to happen will now go into a little more detail on what each letter means patient or population how is you describe your patient what are the most important characteristics of the patient this may include the primary problem disease or coexisting conditions gender age ethnicity or