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This tutorial introduces the PICO model for structuring clinical research questions, fundamental to evidence-based research. The acronym stands for: - **P (Patient or Population)**: Identifying the specific group receiving treatment, including key characteristics like age, gender, ethnicity, and coexisting conditions. - **I (Intervention)**: The specific treatment or therapy being investigated. - **C (Comparison)**: Alternative methods or treatments that will be compared against the intervention. - **O (Outcomes)**: The expected results or impacts of the intervention. The first four components are essential, while the last two Ts (Time and Type) may be optional. The tutorial aims to clarify each part for effective question formulation in research.