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so you know recently the FDA its actually large in the FDA know that the government started passed into law the 21st century cures eight that was right January of this year I think and a lot in there right one of the areas thats talked about is you know the use of real-world evidence in decision-making by the FDA obviously theres more than that the 21st century cures Act but to me thats especially intriguing the idea of moving away from the more classical clinical trial model that weve seen for many years now to the incorporation of other data into the decision making of the FDA right no its a very important topic that lots of people are thinking about let me just start by saying when we when we measure value we have to find data someplace sometimes it comes from randomized clinical trials but inevitably there are questions about what happens after the trial ends what happens to populations who are not exactly like those in the trials and thats where real world evidence comes i