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[soft music] [Jette] The question of how we age has not been answered yet, but our lab thinks it has something to do with the size of stem cells. Stem cells build and maintain the tissues in our bodies. So, for example, blood stem cells, they build the blood system by dividing. But with age, they lose this ability and the blood system becomes less functional. So blood stem cells, like other stem cells, are among the smallest cells in our bodies. So our lab wanted to understand whether the small size of stem cells is important for their function or their ability to divide. We found that when we expose blood stem cells to damaging conditions like irradiation, that the stem cells enlarge in size, and they lose their ability to form new blood cells. But remarkably, when we then treat these damaged stem cells with a drug called a rapamycin, we can prevent this enlargement. And now we see that these small stem cells that still carry DNA damage were able to build new blood cells. So from that