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but with ice or heat sighs now Im the director of the Sacko regulatory science program at NIH before we get started I just want to mention a couple of things about the win our first a very important everyones participation as webinar other than the presenters is needed so if you have questions in the QA period you will have two questions into the Q section on the webinar landing page although we are recording the webinar so well be able to hear it again if you wish and have access to the slides which you will be able to find another webinar give you this I think that they website in there what are you the the website in just a moment if you have any difficulties lets bring or anything like that you can also email the trip loss if youre unable to type youre plugging it to the website so I think all the housekeeping we can move on to the dysplasia okay something I wanted to point out right away is the fact that you note on the first slide that are a number is Cosentino oh six he