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In America, the blood industry is a multibillion-dollar business, valued at $3.3 billion in 2021, with the North American market contributing over 2% to U.S. exports. There is a critical demand for blood, which currently stands at only a one-day supply, leading to sporadic shortages that can have severe consequences for public health. A historic FDA study may reverse the existing ban on blood donations from gay men, as the current ban is criticized for not aligning with scientific evidence. Major companies like Grifols, CSL Plasma, Takeda’s BioLife, and Octapharma dominate blood and plasma collection, where donors are compensated, and the plasma is utilized for therapies by large pharmaceutical firms.