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Down syndrome is a congenial lifelong condition it is not a disease hence it is not treatable although Down syndrome cannot be prevented it can be detected before a child is born Down syndrome is caused by an error in cell division during the development of the embryo whereby it receives an extra copy of chromosome 21 the disorder is associated with a partial or a complete extra chromosome 21 instead of a normal pair trisomy 21 the most frequent kind of Down syndrome disorder has three separate copies of chromosome 21 and 95% of all Down syndrome disorders occur due to it 4% have the extra copy of chromosome 21 because of Robert Sounion translocation and 1% has mosaicism with both normal and trisomy 21 cell lines Down syndrome is also one of the most common chromosomal disorder which is also the frequently recognized cause of intellectual disability the incidence of Down syndrome is estimated to be one in every 1,000 live births worldwide with the total number of people with the disord