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Hi, Iamp;#39;m Dr. Li Iamp;#39;m one of the bladder cancer surgeons at Roswell Park Comprehensive Cancer Center, the most common sign of bladder cancer is what we call gross painless hematuria, meaning patients will see blood in the urine and thereamp;#39;s no pain or infection associate with the bleeding. The other signs could be the bladder irritation symptoms such as urgency, frequency and constant need to urinate. And these could be the early symptoms of the bladder cancer. As a matter of fact, the majority of the patients who have blood in the urine do not have bladder cancer. However, just because you have infection does not mean you do not have bladder cancer. So any patients with the infection who has blood in the urine, they need a complete workup to make sure they donamp;#39;t have cancer. More importantly, the patients with micro hematuria need a complete workup as well. Micro hematuria is that the blood cells are only detected by a urine test because sometimes bladder t