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A blood type refers to the PRESENCE or ABSENCE of a certain marker, or ANTIGEN, on the surface of a persons red blood cells. For example, in the ABO system, presence of A or B antigen gives type A or B, presence of both antigens gives type AB, while their ABSENCE gives type O. Blood typing is critical for blood transfusion, as there are very SPECIFIC ways in which blood types must be MATCHED between the donor and recipient for a safe transfusion. The rule is simple: patients should NOT be given antigens that their own blood does NOT have. This is because the recipients immune system may recognize any NEW antigen as FOREIGN and develop antibodies to target it for destruction. Depending on the scale of the triggered immune response, the reaction can be serious or fatal. Applying the rule, a type A patient, who is NEGATIVE for B antigen, can only receive blood from type A and type O donors, whose blood does NOT contain B antigen. A type AB patient, having both antigens, can receive
