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people who drink regularly could be just one or two drinks per night or it could be somebody that drinks just on Fridays or just on Saturdays or maybe just on the weekend two to four drinks well those people experience changes in their hypothalamic pituitary adrenal axis that result in more cortisol more of this so-called stress hormone being released at Baseline when they are not drinking this is really important people who drink a bit and when I say a bit I donamp;#39;t mean one or two sips or even a glass of wine every once in a while I mean again people that are maybe having one drink a night with dinner and maybe on the weekend a few more and I offer a bunch of different patterns to explain how it could also be two or three drinks on Friday or six drinks only on Saturday well all of those groups experience increases in cortisol release from their adrenal glands when they are not drinking and as a consequence they feel more stressed and more anxiety when they arenamp;#39;t drinki