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well thank you very much for the opportunity to speak today my name is deepa jakemar im assistant professor at uc irvine and a couple disclosures i am a philadelphia native so i have a lot of pride in any reference to philadelphia and i am an adult oncologist so ill do my best to review this you know amazing work in philadelphia like all the title of my talk is all philadelphia negative philadelphia positive and philadelphia like so what you know i dont really have to review this for the entire um the audience here but in general what is a philadelphia chromosome well it was named after city where the first uh first described in leukemia cells in the cml patient with noel and hunkerford in 1960 and then 1973 janet rowley described the philadelphia chromosome was the reciprocal translocation of 922 and its very appropriate that were talking about this given that she recently passed and then the bcr able one fusion gene is generated by joining b cerebral one on chromosome nine with
