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okay i want to talk to you a little bit about immunoglobulin subtypes igg and igm in neuroophthalmology now thereamp;#39;s a lot more to this that iamp;#39;m going to be able to tell you about in this short little video but i just want to tell you the basics of how we need to use this in the in the neural ophthalmology clinic and it doesnamp;#39;t matter whether youamp;#39;re dealing with cat scratch fever which is bartonella or whether youamp;#39;re dealing with rickettsia uh urine typhus or ricketts or or any of these things toxoplasmosis all of them are elises that are using igm and igg to make the diagnosis so as you know generally the igm goes up in the acute phase and then goes down and then the igg goes up and then weamp;#39;ve got some persistence of antibody which is the memory b cell maintained immune response and so if we catch someone early enough both tests might be negative so if youamp;#39;re too early your igm and your igg would be negative fortunately we donamp