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In this video tutorial, the speaker discusses the process of obtaining letters of recommendation, emphasizing the importance of selecting the right individuals to ask. It's recommended to secure 4 to 5 letters, with at least two from science professors, which is considered a standard requirement. Additionally, one letter should be from a non-science professor. Options for other letters include one from a research principal investigator, a physician you've shadowed, and someone from a community or volunteer activity. The speaker stresses the necessity of building strong relationships with potential letter writers, as they should be individuals who know you well.