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Scientists have made progress in slowing and potentially reversing some effects of motor neuron disease (MND), with a new treatment showing effectiveness in 2% of patients. The research, conducted by the University of Sheffield's Neuroscience Institute, has been hailed as a significant breakthrough. Professor Dame Pamela Shaw explains that the treatment targets a faulty sod1 gene, which affects some MND patients. Administered through a lumbar puncture into the cerebrospinal fluid, the therapy reduces levels of the toxic sod1 protein, mitigating its harmful impact on motor neurons. The MND Association expresses growing confidence in this promising approach.