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theres two things that Im really excited about that Id like to talk about briefly one is yesterday I sat in the audience and watched us change Dogma we have now heard the recommendations for the 2017 revision of the macdonald criteria what im saying is as weve redefined how we diagnose ms and so as you look at the diagnostic criteria going back from the 80s forward we become faster and faster and faster and moving from 2010 to 2017 criteria weve done that yet again by reintroducing the use of spinal fluid early on with clinically isolated syndrome we can confirm an immense diagnosis much faster this is very important because the quicker we can make the diagnosis the faster we can initiate disease modifying therapy data is outstanding proving the point that the earlier the better and so that was very exciting to participate in that audience Im also very excited at some of the long term follow-up data when you do a two-year clinical trial its a very short Epoque ms is measured b