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In this video tutorial, the speaker discusses obtaining letters of recommendation, which can be a daunting task. It is advised to have 4 to 5 letters, with at least two from science professors, as this is a general requirement. Additionally, one letter should come from a non-science professor. Other potential sources include a research PI, a physician you have shadowed, and someone from a community or volunteer activity you are involved with. While not all letters are mandatory, strengthening relationships with letter writers is crucial, as they should know you well to provide meaningful recommendations.