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In America, the blood industry is a multibillion-dollar market, valued at $3.3 billion in 2021, with U.S. blood exports constituting over 2% of total exports. However, there is a critical shortage, currently at just a one-day supply, which poses life-threatening consequences. The industry faces challenges, including a historic FDA study to potentially lift the ban on blood donations from gay men, highlighting that current regulations do not align with scientific evidence. Major companies like Grifols, CSL Plasma, Takeda's BioLife, and Octapharma dominate blood collection, especially plasma, for therapeutic use, often compensating donors. Blood remains a vital public health resource despite existing hurdles.