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In this video, Tiffany Ashton discusses the important topic of protocol amendments for clinical trial managers. She explains that every clinical study follows a protocol, which serves as a set of guidelines for the study team, including CRAs, coordinators, and investigators. Occasionally, sponsors propose updates to the protocol to incorporate new safety information, procedures, or processes. Ashton emphasizes the significance of understanding the implications of these protocol amendments for clinical trial managers, outlining the necessary steps to take upon receiving one to ensure compliance and effective study management.