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In today's session, we explore iron metabolism, iron overload, and therapeutic phlebotomy for individuals with high ferritin and hemoglobin, particularly affecting men of all ages and post-menopausal women. Many individuals unknowingly experience subclinical iron overload, yet treatment is straightforward: bloodletting, or donating blood once or twice a year, can reduce stored iron levels. Elevated iron acts as a catalyst, facilitating the oxidation of low-density lipoproteins in atherosclerotic plaque. The discussion includes key blood biomarkers and indicators to monitor for elevated iron levels.