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Mark Esplind, a professor of gerontology and biostatistics, discusses the strong association between tobacco use and dementia risk. Numerous studies indicate that smoking can significantly increase the likelihood of cognitive decline and potentially dementia, with heavy smoking in middle age potentially doubling the risk later in life. However, evidence also suggests that quitting smoking can reduce these risks to levels similar to those who have never smoked. The 2020 Lancet Commission assessed modifiable risk factors for dementia and identified smoking as a crucial target for intervention, emphasizing its importance in reducing dementia risk later in life.