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[Music] Im Mark esplind Im a professor of gerontology and biostatistics at the Wake Forest School of Medicine in Winston-Salem North Carolina happy to be here to talk about associations between tobacco use and risk of dementia theres compelling evidence from many many studies that smoking increases the risk of cognitive decline and possibly improbably dementia heavy smoking in middle age May double the risk for dementia later in life but its also a very strong evidence that the quitting smoking reduces risks even to levels comparable to those that have never smoked the Lancet Commission in 2020 was assembled to evaluate which modifiable risk factors should be targeted most effectively to reduce the risk of dementia I was looking to see if this risk factor was targeted what would be the impact on dementia later on this figure you could see that among those risk factors that could be targeted later in life they felt like the most important would be smoking that it might have more of