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Dr. Rishi Desai from Osmosis discusses three essential tips for taking a comprehensive patient history. While the mechanics include understanding the chief complaint, history of present illness (HPI), past medical history, medications, allergies, family and social history, and a review of systems, the focus is on improving the process. The first tip emphasizes the importance of listening well and empathizing with patients. He notes that patients can find basic information from automated sources, but the human connection and understanding are irreplaceable. By genuinely engaging with patients, healthcare providers can gather more meaningful insights and foster trust.