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Modifiable Risk Factors and Comorbidities for Severe COVID-19 Infection The severity of COVID-19 varies widely based on pre-existing conditions. Those with high blood pressure are at twice the odds of suffering a severe course, and those with cardiovascular disease 3 times the odds. Whats more, those with either condition are about 4 times more likely to end up in the ICU. Those with COPDchronic obstructive pulmonary diseases like emphysema appear to be at the highest risk with 6 times the odds of a severe course for COVID-19, and nearly 18 times the odds of admission to an intensive care unit. We know that exposure to air pollution can increase susceptibility to respiratory viral infections, and that may be the case with COVID-19 as well, as higher pollutant levels appeared to be correlated with pandemic deaths. But just as air pollution may influence COVID-19, COVID-19 may be influencing air pollution. Check out this satellite data from NASA. This is nitrogen dioxide pollutant