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The severity of COVID-19 is significantly influenced by pre-existing conditions. Individuals with high blood pressure face twice the likelihood of severe infection, while those with cardiovascular disease have three times the likelihood. Moreover, having either condition increases the chance of ICU admission fourfold. Chronic obstructive pulmonary diseases (COPD), like emphysema, pose the highest risk, with six times greater odds of severe COVID-19 and nearly 18 times greater odds of ICU admission. Additionally, exposure to air pollution may heighten susceptibility to respiratory infections, including COVID-19, with higher pollutant levels linked to increased pandemic deaths. Conversely, COVID-19 may also impact air pollution levels, as indicated by NASA's satellite data on nitrogen dioxide.