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In America, the blood industry is a multibillion-dollar sector, valued at $3.3 billion in 2021, with over 2% of U.S. exports comprising blood products. The high demand and lack of substitutes for human blood create challenges, with current supplies being critically low and resulting in sporadic shortages that can impact public health. Additionally, there are ongoing issues regarding donor eligibility, particularly for gay men, as the FDA studies the possibility of lifting a long-standing ban that is criticized for not aligning with scientific evidence. Major companies like Grifols, CSL Plasma, Takeda's BioLife, and Octapharma dominate blood collection, especially in plasma, which is compensated and used in pharmaceutical therapies.