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In America, the blood industry is a multibillion-dollar market, valued at $3.3 billion in 2021. It accounts for over 2% of U.S. exports, with demand often outstripping supply, leading to potential life-or-death shortages. Currently, the nation faces a one-day supply of blood, indicating ongoing sporadic shortages. There are challenges for certain groups regarding blood donations, particularly gay men, as a historic FDA study may reverse existing bans seen as not grounded in scientific evidence. Major companies like Grifols, CSL Plasma, Takeda's BioLife, and Octapharma dominate the blood collection market, primarily focusing on plasma donations, which are compensated and used for therapies by large pharmaceutical firms.