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Dr. Rishi Desai discusses three key tips for taking an effective patient history. He emphasizes the importance of not just knowing the mechanics—such as the chief complaint, History of Present Illness (HPI), past medical history, medications, allergies, family history, and review of systems—but also excelling at gathering this information. His first tip is to actively listen and empathize with patients, acknowledging that they seek human interaction over automated responses. This approach ensures patients feel understood, which is vital for building trust and gathering accurate medical histories.