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heart failure is a clinical syndrome that occurs when the heart is unable to meet the perfusion demands of the body generally this can happen either because the heart is unable to pump the blood effectively known as systolic heart failure or heart failure with a reduced ejection fraction or because the heart is not filling with blood correctly known as diastolic heart failure or heart failure with a preserved ejection fraction important definitions to know include the cardiac output which is the volume of blood pumped per minute and is given by the stroke volume multiplied by the heart rate the stroke volume is the volume of blood pumped in one beat and is typically around 70 milliliters which when multiplied by a resting heart rate of around 70 beats per minute gives a cardiac output of nearly 5 liters per minute systole means the contraction of the ventricles when blood is being pumped out while diastole is the relaxing or filling time where the ventricles are filling with blood not
