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In this lecture on PET imaging in nuclear medicine physics, we learn that PET stands for positron emission tomography. Positron is a component of an electron and when they meet, they annihilate, resulting in the emission of two photons. By detecting these photons emitted back to back with a ring of detectors, we can determine the source of the radiation inside the body. This process differs from SPECT imaging, where only a single photon is emitted. Various types of radioisotopes that emit positrons are also discussed for use in PET imaging.