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hello friends welcome to bmh learning this video is about linkage disequilibrium linkage disequilibrium refers to the known random association of alleles at a pair of genetic loci it manifests as the deviation of observed haploid type frequencies from the frequencies expected under the assumption that alleles at the two loci associate independently in simple words loci are said to be in linkage disequilibrium when the frequency of association of their different alleles is higher or lower than what would be expected if the loci were independent and associated randomly example human leukocyte antigen that is hla alleles hla constitutes a group of cell surface antigens also known as the mhc of humans because atala genes are located at adjacent loci on the particular region of a chromosome and presumed to exhibit epistasis with each other or with other genes a sizable fraction of alleles are in linkage disequilibrium an example of such linkage this equilibrium is between hla a1 and b8 all...