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Professor Dave again, lets map some genes. We just looked at some early experiments regarding X-linked genes, which produced some of the first overwhelming evidence for the chromosome theory of inheritance. This set the stage for further efforts, largely by Thomas Hunt Morgan and his flies whom we previously introduced, so lets take a look at what happened next. First lets discuss how linkage affects inheritance in general. Humans have just 23 pairs of homologous chromosomes, but each chromosome contains hundreds or even thousands of genes. Thus it is logical that many or most of the genes on a particular chromosome are inherited together. However we now know that homologous chromosomes cross over during the prophase I of meiosis, producing recombinant chromosomes, so it will not be the case that 100% of the genes on a chromosome will be passed on to the offspring produced by fertilization of a particular gamete. This was not known by Morgan, but he did some work that set the stage
