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hello everybody thank you for joining us tonight for road map webinar 201 natural history power of the patient experience translating natural history data into research breakthroughs im ricky safer psc patient and ceo of psc partners seeking a cure tonight we are really excited to unveil psc partners new natural history initiative now referred to by the acronym win worldwide integration of natural history databases in tonights session patients will learn how patient participation in natural history studies drives psc research and drug development the impetus for starting this initiative was patient feedback about the unmet need to identify new treatment options to stop progression of psc after tonights webinar if youd like to learn more about our wind initiative please go to the research tab on our website where we have a basic review of all of tonights information thank you to the sponsors of our roadmap initiative albireo intercept eschent miram and sima bay next slide please th