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mouse models have generated important insights that have revolutionized cancer therapy in the immuno oncology age there are essentially two different types of models used in preclinical immuno oncology research first are the sin genetic models in which a mouse tumor is implanted into a genetically identical and immunocompetence host since the tumor cells and the hosts immune system are matched with respect to histocompatibility low sigh this tumor is not rejected by the host immune system inbred strains are invaluable for these studies as they provide a consistent genetic background chin genetic models have several advantages firstly the host has a fully intact endogenous immune system making it possible to study numerous mechanisms of tumor immune interaction secondly the tumor is genetically matched not only with the immune system but also with the tumor stroma finally genetically engineered mouse models on defined inbred backgrounds make it possible to study a wide range of mechanis