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- [Voiceover] After a polypeptide chain is formed, its going to be folded into its secondary and tertiary structure into a very specific 3D conformation or shape. And at this point, we can start calling it a protein. But, this protein may not be ready to carry out its function just yet. There might be some additional protein modifications that need to be made to this protein before it can be functional. And those are called protein modifications. There are two different types of protein modifications. The first type is co-translational modification. And that means that these are modifications or changes that happen to the protein, or actually to the polypeptide while its being translated. Lets say we have the ribosome right here and we have a polypeptide thats being formed. So these changes are going to happen while the polypeptide is being formed. An example of a co-translational modification is acetylation. And what happens during acetylation is, the first amino acid in the polyp