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welcome back to walking the line firm research to practice this is episode 2 Im Celine Roos I an ER physician down here in San Antonio Texas and in episode two were gonna be talking about the peg trial which was a prospective trial not a randomized clinical trial and in this study they were looking at adjusting d-dimers for clinical probability and their ability to rule out vino thromboembolism now once a patient was enrolled in the study what the authors did is they applied a well score and I like this because Wells is very well validated and something that we use all the time it doesnt mean that there arent other tools we can use to risk assess patients but I like the fact that they use this one and what they did is they put patients into three categories either low-risk moderate risk or high risk once the patients were put into a category the d-dimer was adjusted so for the low-risk patients a typical cutoff would have been 500 nanograms per milliliter but in this study they we