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Murphys Sign Ask the patient to exhale, while palpating the gall bladder area, medial to the mid-clavicular line. Now instruct the patient to take a deep breath so the gall bladder is pushed down, and against the examiners fingertips, as the lungs expand. If cholecystitis is present, the patient will experience a sharp and sudden pain, causing them to abruptly cease inhalation. This reaction is known as a positive Murphys Sign.
