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the use of micro needles in the gastrointestinal tract presents a unique opportunity to enable the oral delivery of large molecules like insulin that are currently limited to injection an ingestible capsule such as the one shown could be imagined it would contain a reservoir to house the therapeutic payload and have a pH responsive coating to cover the needles allowing for easy ingestion after ingestion the pill would pass through the stomach and enter the intestine there the coating would dissolve revealing the micro needles the peristaltic motion of the tissue would compress the reservoir expelling the drug out of the needles and into the tissue insulin injections were tested in the GI tract of pigs as a result of injection a small bubble can be seen in the tissue this small injection results in a robust drop in the animals blood glucose that superior to the effect elicited by traditional subcutaneous injection oil administration as expected has no effect the safety and passage of th
