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This Is how lethal injection actually works. Lethal injection is Americas most common method of execution! There have been 1,472 executions in America since 1976, and 1,297 of these have been performed via the lethal injection. The actual injection involves three different chemicals, applied concurrently via intravenous drip. The first injection is an anesthetic called sodium thiopental, a strong barbiturate used to send a person into a deep unconsciousness state, so pain cannot be felt. The second is pancuronium bromide, which acts as a neuromuscular blocker, preventing communication between the nervous system and muscles. As the person has no muscular control, a state of paralysis is docHubed. And the final injection is potassium chloride, This disrupts the electrical signaling of the heart, stopping it from beating and ending the persons life. ing to a 2002 study in the Journal of Forensic Science, the average time from the first injection to the heart stopping, is 8.4 minutes.