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knee joint injections are commonly used to help relieve pain caused by osteoarthritis the knee joint is a space between the femur the thigh bone and the tibia the shin bone the patella or kneecap sits in front surrounding the joint is a capsule a knee joint injection is successful when the needle is placed through the joint capsule and into the joint space there are several good injection sites that lead into the knee joint which injection site is used is not usually important as long as the end of the needle ends up within the joint capsule the injection site is felt and identified the skin is cleansed and sterilized the needle is introduced into the joint sometimes a cold spray is used to numb the injection site the medicine is injected and the needle withdrawn the knee is wiped clean and dressed with a band-aid