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some people with diabetes donamp;#39;t realize there are risks associated with using needles more than once when injecting insulin pen needles and insulin syringes are designed for single use in addition to a more comfortable insulin injection experience research shows that using a new needle and rotating to a healthy site every time you inject may reduce your risk of developing hard lumps beneath the skin called lipo hypertrophy injecting into lipo hypertrophy can cause inconsistent insulin absorption inject with confidence replace your needle rotate injection sites remembering these two simple steps every time you inject can make a real difference in your injection experience