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the fastest lateralis the vastus lateralis muscle is a insight for intramuscular injection first locate the greater trochanter of the femur the top border of the vastus lateralis muscle can be found a hand with below the groin the bottom border of the vastus lateralis muscle is found a hand above the knee the side borders are from the mid anterior thigh to the mid lateral thigh here is an ideal site for injection squeezing the muscle before injection increases the thickness and depth of the muscle and avoids nerve injuries make sure you do not advance the needle deep to touch the bone aspirate before you inject you