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I think the prevalence of germline BRCA mutations is a bit tricky to fully understand because weamp;#39;re not clear what the ultimate denominator is what Iamp;#39;ve taken away from the data presented is that there are clearly women out there who should have clinical genetic testing based on NCCN guidelines and I would first want to be sure that those patients who are candidates for testing are aware of their germline BRCA status the data prior to San Antonio that we had was related to the PARP inhibitor elaborate so mark Robson presented the data at ASCO for the Olympiad study and there we saw single agent elaborate oral therapy was superior to treatment of physicians choice chemotherapy and that arm included Capeside abena Ritalin or vinner Albion and a lap rib had about a forty ish percent improvement in median progression-free survival for women with journalling BRCA mutations with metastatic disease and the safety profile was very tolerable relative to cytotoxic chemoth
