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welcome to your step-by-step guide to injecting with the prolia pre-filled syringe if youamp;#39;ve been prescribed prolia you can give yourself your injection as long as you have been properly trained letamp;#39;s walk through the steps for self-injection together when you bring your prolia prescription home from the pharmacy store it in your refrigerator between 2 degrees celsius and 8 degrees celsius until ready for use do not freeze prolia store prolia in its original carton in order to protect it from light before you begin your injection your pre-filled syringe may be taken out of the refrigerator for 15 to 30 minutes to allow it to docHub room temperature this will make the injection more comfortable after it is removed from the refrigerator prolia must be kept at room temperature up to 25 degrees celsius in the original carton and must be used within 30 days begin by gathering the materials you will need including cotton swabs and band-aids wash your hands thoroughly w