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glute or buttock injection is a universal procedure that is commonly used around the world the injection has to be safe selecting the proper site that avoids injury to the neurovascular structures is important the sciatic nerve could be at risk for injury during buttock injection how do we make the injection safe the buttock is divided into quadrants divide the buttock halfway down the middle and halfway across Injection is given in the center of the upper outer quadrant avoid the other quadrants injection into the other quadrants may cause injury to the neurovascular structures and damage the sciatic nerve another helpful method that could confirm a safe site for injection is to draw a line from the posterior superior edge of the iliac spine to the greater trochanter the area above the line is considered to be the safe zone for intramuscular injection this corresponds with the upper outer quadrant of the buttock and is the exact safe site for buttock injection thank you very much I h