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The fetlock joint can be injected with the limb lifted and the joint slightly flexed or with the leg in the extended position. The needles is inserted in the synovial pocket that is located in the space between the third metacarpal or metatarsal bone, the distal end of the fourth metacarpal or metatarsal bone, and the lateral branch of the suspensory ligament. To assure aseptic conditions, the hair over the injection point must be clipped and the skin must always be carefully disinfected before arthrocentesis. The needle is aimed in the approximate direction of the medial proximal sesamoid bone. If there is no spontaneous flow of synovial fluid from the fetlock, aspiration with the syringe can confirm that the tip of the needle is inside the joint. If this is not successful, saline can be injected to clear the orifice of the cannula and to increase the pressure in the joint.