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- [Bapu] Welcome everyone. Iamp;#39;m Bapu Gaddam Quality Reviewer from Division of Lifecycle API. In this presentation I will discuss a word recommended documentation for API sameness for synthetic therapeutic polymers, Specifically cross-couple polymers. For the approval of gender drugs, the API sameness is required to show pharmaceutical equivalency. It is considered same API as RLD, if it possess same physical and chemical characteristics as RLD. I will be showing a few examples of cross-couple polymers and discussing the way to approach to determine the API sameness of this kind of complex molecules. This is the title of the poster presentation. Synthetic Therapeutic Polymers: Recommended Documentation for APA sameness. In this slide Iamp;#39;m showing three examples for a cross-couple polymers. In cross-couple of polymers, two or more polymer chains are coupled together with linked up portions. Here, the first example, sevelamer which is derivative of polyallyamine cross-couple