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this video reviews the pain medication research for sciatica itamp;#39;s based on a research review published in the British medical journal shown here and referenced in the description the first intervention for sciatica related pain is typically medication but how effective is medication for sciatica and what are the best options paracetamol is considered to be no more effective than a placebo for standard lower back pain and no high quality studies exist to consider its Effectiveness for s I so paracetamol if it does have any benefit is likely to Simply Be from the placebo mechanism overall non-steroidal anti-inflammatory drugs like ibuprofen are no more effective than PBO in reducing pain or disability associated with sciatica while there may be some benefit short term the side effects of prolonged use should be considered alongside the weak evidence for their use benzo diazines like diazapam also have been sh shown to be no more effective than Placebo and in one small trial the d